High Prevalence of Clarithromycin Resistance and cagA , vacA , iceA2 , and babA2 Genotypes of Helicobacter pylori in Brazilian Children

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High prevalence of clarithromycin resistance and cagA, vacA, iceA2, and babA2 genotypes of Helicobacter pylori in Brazilian children.

We isolated 45 Helicobacter pylori strains from 217 child patients. Resistance to clarithromycin, metronidazole, amoxicillin, and tetracycline was detected in 27%, 13%, 4%, and 0% of strains, respectively. The A2143G mutation was the most prevalent (67%) among clarithromycin-resistant strains. In addition, strain genotyping revealed a significant association between gastritis severity and the s...

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Prevalence of Helicobacter pylori cagA, vacA, iceA, babA2 genotypes in Polish children and adolescents with gastroduodenal disease* Częstość występowania genów wirulecji cagA, vacA, iceA, babA2 wśród szczepów H. pylori izolowanych od dzieci i młodzieży z chorobami przewodu pokarmowego

Infection with Helicobacter pylori is a major cause of chronic gastritis and peptic ulcer disease in children and its consequences in adulthood can lead to serious complications, including in particular the development of gastric cancer. Our aim was to analyze the relationship between the occurrence of selected genes such as cagA, vacA, iceA, and babA2 determining pathogenicity of H. pylori str...

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ژورنال

عنوان ژورنال: Journal of Clinical Microbiology

سال: 2010

ISSN: 0095-1137,1098-660X

DOI: 10.1128/jcm.01034-10